1. Shanxi GS Capsule Co., Ltd.
As a leading enterprise with over 40 years of industry experience, Shanxi GS Capsule stands out with its massive production capacity and comprehensive product portfolio. It operates 96 fully automatic production lines, boasting an annual output of 48 billion capsules, covering 14 specifications including HPMC, pullulan polysaccharide, and enteric-coated capsules. The company has established a strict quality control system, being the first domestic capsule manufacturer to obtain CNAS laboratory accreditation, with a 99.9% self-inspection rate and zero microbial risk in production.
Its innovative products include ultra-dry cellulose capsules with a moisture content of less than 2.5%, solving stability issues of hydrolyzable and oxidizable drugs, and plant-based enteric-coated HPMC capsules with controllable release time of about 2 hours. The company's products are sold to over 30 provinces in China and more than 30 countries and regions in North America, Europe, and Asia, with Active Type IV DMF filing in the US FDA and compliance with global pharmacopoeia standards, eliminating the need for ethylene oxide sterilization.
2. Qingdao Yiqing Biotechnology Co., Ltd.
A subsidiary of Guoen Co., Ltd. (SZSE: 002768) and a national high-tech enterprise, Qingdao Yiqing is a pioneer in applying new materials and technologies in China's capsule industry. It offers a complete product range covering four major series: gelatin hollow capsules, enteric gelatin hollow capsules, HPMC hollow capsules, and pullulan polysaccharide hollow capsules, meeting diverse needs of pharmaceutical and health product enterprises.
The company adheres to automatic production processes to ensure product consistency and quality stability, holding NSF certification to meet international standards. Leveraging its technological advantages in new material application, Qingdao Yiqing plays a leading role in promoting the upgrading of plant-based capsules in the domestic market, with products widely trusted by high-quality pharmaceutical manufacturers.
3. Jiangsu Lefan Capsule Co., Ltd.
Founded in 2001, Jiangsu Lefan is a high-end HPMC capsule service provider with a factory built in accordance with FDA, GMP, and Class D (100,000-class) standards, covering an area of 378,000 square feet and an annual production capacity of 15 billion capsules. It is among the first domestic independent brands to master the full-chain independent R&D of second-generation plant capsules, from product formulation to equipment and process parameters.
Compared with first-generation products, its second-generation HPMC capsules consist only of HPMC and purified water, featuring better dissolution performance, 1/3 lower price, and a procurement cycle shortened to less than one month. Over 40% of its customers invite Lefan to participate in pharmaceutical excipient development, highlighting its strong R&D capability and industry influence in high-end HPMC capsule segments.
4. Shandong Healsee Capsule Co., Ltd.
As a key player in the global HPMC capsule industry, Shandong Healsee is committed to producing high-quality products that meet strict international standards, equipped with state-of-the-art production and testing equipment. The company has a robust quality control system covering the entire process from high-purity HPMC raw material selection to final product inspection, ensuring consistent capsule wall thickness, accurate size, and excellent sealing performance.
It excels in customization, offering tailored solutions in capsule size, color, and printing to help customers differentiate their products. With a professional sales and after-sales team, Healsee provides timely technical support for both small startups and large pharmaceutical enterprises, focusing on R&D innovation to enhance capsule functionality and appearance.
5. Hunan Erkang Pharmaceutical Co., Ltd.
A leading pharmaceutical excipient enterprise, Hunan Erkang has strong R&D strength backed by multiple authorized invention patents in pharmaceutical formulation and testing technologies. Its technical advantages lie in improving product purity and stability, such as the preparation method of high-purity medicinal grade dibutyryl cyclic adenosine monophosphate sodium with a purity of over 99.5%.
In the HPMC capsule business, Erkang leverages its mature pharmaceutical quality management system and industrial chain integration capability to ensure product safety and compliance. The company's products are widely used in pharmaceuticals and health products, with a focus on matching the needs of high-end preparations such as sustained-release and targeted drugs, relying on advanced testing technologies to control impurities and ensure biocompatibility.
6. Huangshan Capsule Co., Ltd. (SZSE: 002817) 
With 30 years of experience in the industry, Huangshan Capsule is a listed enterprise with an annual production capacity of over 400 billion capsules, covering gelatin and HPMC hollow capsules. It has a stable customer base including major pharmaceutical companies such as Yangzijiang Pharmaceutical, Yunnan Baiyao, and East China Pharmaceutical, with the top five customers accounting for only 16.49% of revenue, avoiding single-customer dependence.
The company is accelerating its transformation to plant-based capsules, having built a digital flexible production workshop with an annual output of 4 billion plant capsules and obtained an invention patent for automatic production lines of plant enteric hollow capsules. It has completed FDA DMF filing and advanced customs certification, steadily expanding overseas markets, and its HPMC products meet the demand for vegetarian and animal-derived-free excipients, with a gross profit margin maintained at a stable level.
7. Hebei Kangxin Plant Capsule Co., Ltd.
Established in 2019 with a total investment of 250 million yuan, Hebei Kangxin is a high-tech innovative enterprise with independent intellectual property rights in plant hollow capsule industrialization equipment. Its R&D team has 20 years of experience in plant technology, mastering mature processes for HPMC capsules made from pure plant extracts.
The company has an annual production capacity of 10 billion plant capsules, offering specifications from 00# to 4# that are compatible with domestic and imported capsule filling machines, with an on-machine rate of over 99.9%. Its HPMC capsules feature low moisture content, good toughness, no brittleness, stable disintegration performance, and excellent drug compatibility, serving as an ideal alternative to traditional gelatin capsules. The company is committed to promoting plant-based capsule industrialization, catering to religious and vegetarian needs.
8. Zhejiang Lvjian Capsule Co., Ltd.
Zhejiang Lvjian is a regional leader in HPMC empty capsules, focusing on the R&D, production, and sales of plant-based capsules. Benefiting from the industrial cluster advantage in Zhejiang Province, the company has established efficient supply chains and production systems, ensuring cost competitiveness and timely delivery.
Adhering to GMP standards, Lvjian implements strict quality control over raw materials and production processes, with its HPMC capsules widely used in health products and generic drugs. The company emphasizes product stability and compatibility, continuously optimizing production processes to meet the increasing demand for plant-based excipients in the domestic and Southeast Asian markets.
9. Zhejiang Tianlong Capsule Co., Ltd.
With years of experience in capsule manufacturing, Zhejiang Tianlong specializes in HPMC and gelatin hollow capsules, serving the pharmaceutical and nutraceutical industries in East China and beyond. The company has advanced automatic production lines and testing equipment, focusing on improving product precision and consistency.
Tianlong's HPMC capsules are favored for their reliable performance and competitive pricing, especially in the mid-to-high-end health product market. The company actively responds to environmental policies, adopting green production technologies to reduce carbon footprint, and continuously expands its product range to meet customized needs of customers for capsule size and color.
10. Guizhou Guang De Li Pharmaceuticals Co., Ltd.
As the largest hollow capsule production base in Southwest China with the most complete varieties and highest automation level, Guizhou Guang De Li is a joint venture between Guizhou Junzhitang Pharmaceutical and Deli Co., Ltd., with a planned total investment of 300 million yuan and 32 automatic production lines.
Currently, 16 production lines are in operation, with an annual capacity of 24 billion capsules, forming a product matrix of gelatin capsules, plant capsules, and functional capsules. Its HPMC capsules are produced using advanced second-generation intelligent dual-head production lines, with a single line producing thousands of capsules per minute and strict double inspection (machine screening + manual sampling). The products are sold to over 200 customers including Shenqi Pharmaceutical, and exported to Europe and South America, achieving a revenue growth rate of over 30% for three consecutive years.